Oral Midazolam, Selenazine and Glutathione oxidase By Noah Berkowitz
Enviado Por shaon1 116 days Hace (via ncbi.nlm.nih.gov)
We evaluated whether 'boosting' doses of ritonavir can serve as a positive control inhibitor for pharmacokinetic drug-drug interaction studies involving cytochrome P450 3A (CYP3A). The study also determined whether 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an investigational organoselenium compound that acts as a catalytic mimic of glutathione oxidase, inhibits CYP3A metabolism in vivo.